Nattokinase

Key Finding: Nattokinase possesses a variety of favourable cardiovascular effects including fibrinolytic, antithrombotic, antihypertensive, antiatherosclerotic, lipid-lowering, cytoprotective, and antiplatelet activities. High natto intake was associated with decreased risk of total CVD mortality.

Key Finding: Nattokinase supplementation resulted in a significant reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP). These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.

Key Finding: Randomized, double-blind, placebo-controlled trial. Nattokinase consumption in a North American population is associated with beneficial changes to blood pressure in a hypertensive population. Also reduced von Willebrand factor, a cardiovascular risk marker.

Key Finding: Nattokinase is a potent blood-clot dissolving protein used for the treatment of cardiovascular diseases. It enhances fibrinolysis and anti-coagulation via several different pathways simultaneously, making it a promising oral antithrombotic agent.

Key Finding: In addition to its thrombolytic and anticoagulant activities, nattokinase elicited anti-inflammatory and anti-oxidative stress effects. NK markedly inhibited LPS-induced inflammation and oxidative stress, suggesting a novel anti-inflammatory role.

Key Finding: Systematic review and meta-analysis of randomized controlled trials evaluating the cardiovascular efficacy of nattokinase. Confirmed beneficial effects on blood pressure and cardiovascular risk markers.

Key Finding: Review of nattokinase's fibrinolytic, antithrombotic, anti-inflammatory, and antioxidant effects. Studies show natto reduces the risk of cardiovascular disease mortality due to its fibrinolytic and antithrombotic properties.

Key Finding: A single-dose of nattokinase administration enhances fibrinolysis and anti-coagulation via several different pathways simultaneously, demonstrating its potential as an oral thrombolytic agent.